TRANSPLANTATION OF NEURAL PRECURSOR CELLS ATTENUATES CHRONIC IMMUNE ENVIRONMENT IN CERVICAL SPINAL CORD INJURY

Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury

Inflammation after traumatic spinal cord injury (SCI) is non-resolving and thus still present in chronic injury stages.It plays a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and development of neuropathic pain.Neural precursor cells (NPCs) have been shown to reduce the acute and sub-acute inflammato

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Gene Frequencies of Methylmalonic Acidemia Disease at the Global Level and Compiling the Pathogenic Mutations in the Iranian Population

Background: Methylmalonic acidemia (MMA) is a rare autosomal recessive metabolic disorder resulting from a genetic defect in methylmalonyl-CoA mutase (MCM) or a defect in the biosynthesis of its cofactor, adenosyl-cobalamin (AdoCbl).The disease is caused by a mutation in six main genes (MUT, MMAA, MMAB, MMADHC, MMACHC, and MCEE).In this investigati

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